Shuvo Roy, PhD

Professor
Surgical Innovations Team
+1 415 514-9666

Shuvo Roy, PhD, is a bioengineer focusing on the development of medical devices to address unmet clinical needs through strong collaboration and a multidisciplinary approach.

Dr. Roy is a professor at the University of California, San Francisco in the Department of Bioengineering and Therapeutic Sciences (BTS), a joint department of the UCSF Schools of Pharmacy and Medicine, and is a faculty affiliate of the California Institute for Quantitative Biosciences (QB3). He is the director of the Biodesign Laboratory located on the Mission Bay campus. In addition, he serves as the Technical Director of The Kidney Project and is a founding member of the UCSF Pediatric Device Consortium. He has developed and currently teaches a course on medical devices, diagnostics, and therapeutics and regularly lectures on the medical device design process to UCSF graduate students and to national and international academic and industry audiences. He is the author of more than 100 publications and co-author of three book chapters, and holds multiple patents for device developments.

Before joining UCSF in 2008, Roy co-directed the BioMEMS Laboratory in the Department of Biomedical Engineering at Cleveland Clinic in Cleveland, Ohio, focusing on clinical applications of MEMS. In 1992 he earned a BS degree, magna cum laude, for triple majors in physics, mathematics, and computer science, from Mount Union College in Alliance, Ohio. In 1995, he earned an MS in electrical engineering and applied physics and, in 2001, he earned a PhD in electrical engineering and computer science, both from Case Western Reserve University in Cleveland, Ohio.

He is the recipient of a Top 40 under 40 award by Crain’s Cleveland Business in 1999 and the Clinical Translation Award at the 2nd Annual BioMEMS and Biomedical Nanotechnology World 2001 meeting. In 2003, Dr. Roy was selected as a recipient of the TR100, which features the world’s 100 Top Young Innovators as selected by Technology Review, the Massachusetts Institute of Technology’s Magazine of Innovation. In 2004, he was presented with a NASA Group Achievement Award for his work on harsh environment MEMS. In 2005, Dr. Roy was named as a Who’s Who in Biotechnology by Crain’s Cleveland Business. In 2005 and 2007, he was recognized as a Cleveland Clinic Innovator. In 2009, he was nominated for the Biotechnology Industry Organization's Biotech Humanitarian Award, which is given in recognition of an individual who has used biotechnology to unlock its potential to improve the earth. In 2012, he was presented the Rising Star Award by BayBio Pantheon, and in that same year, he received the Innovation Pathway 2.0 Award from the Food and Drug Administration (FDA). Most recently, he was recognized as a Fellow by the Applied Innovation Institute in 2013.

Publications: 

Treating the kidneys - a new era in the United States (and beyond).

Nature reviews. Nephrology

Fissell WH, Roy S

Application of physiological shear stress to renal tubular epithelial cells.

Methods in cell biology

Ferrell N, Sandoval RM, Molitoris BA, Brakeman P, Roy S, Fissell WH

Compliance monitoring via a Bluetooth-enabled retainer: A prospective clinical pilot study.

Orthodontics & craniofacial research

Castle E, Chung P, Behfar MH, Chen M, Gao J, Chiu N, Nelson G, Roy S, Oberoi S

Apical Shear Stress Enhanced Organic Cation Transport in Human OCT2/MATE1-Transfected Madin-Darby Canine Kidney Cells Involves Ciliary Sensing.

The Journal of pharmacology and experimental therapeutics

Jayagopal A, Brakeman PR, Soler P, Ferrell N, Fissell W, Kroetz DL, Roy S

In vitro and in vivo hemocompatibility assessment of ultrathin sulfobetaine polymer coatings for silicon-based implants.

Journal of biomaterials applications

Iqbal Z, Kim S, Moyer J, Moses W, Abada E, Wright N, Kim EJ, Park J, Fissell WH, Roy S

Substrate Elasticity Governs Differentiation of Renal Tubule Cells in Prolonged Culture.

Tissue engineering. Part A

Love HD, Ao M, Jorgensen S, Swearingen L, Ferrell NJ, Evans RC, Gewin L, Harris RC, Zent R, Roy S, Fissell WH

Orbital Shear Stress Regulates Differentiation and Barrier Function of Primary Renal Tubular Epithelial Cells.

ASAIO journal (American Society for Artificial Internal Organs : 1992)

Ferrell N, Cheng J, Miao S, Roy S, Fissell WH

Acoustic Methods for Pulmonary Diagnosis.

IEEE reviews in biomedical engineering

Rao A, Huynh E, Royston T, Kornblith A, Roy S

Evaluation of silicon membranes for extracorporeal membrane oxygenation (ECMO).

Biomedical microdevices

Abada EN, Feinberg BJ, Roy S

Innovations in Wearable and Implantable Artificial Kidneys.

American journal of kidney diseases : the official journal of the National Kidney Foundation

Salani M, Roy S, Fissell WH

Improved Detection of Lung Fluid With Standardized Acoustic Stimulation of the Chest.

IEEE journal of translational engineering in health and medicine

Rao A, Chu S, Batlivala N, Zetumer S, Roy S

Stem Cell Therapies for Treating Diabetes: Progress and Remaining Challenges.

Cell stem cell

Sneddon JB, Tang Q, Stock P, Bluestone JA, Roy S, Desai T, Hebrok M

Combined In Silico and In Vitro Approach Predicts Low Wall Shear Stress Regions in a Hemofilter that Correlate with Thrombus Formation In Vivo.

ASAIO journal (American Society for Artificial Internal Organs : 1992)

Buck AKW, Groszek JJ, Colvin DC, Keller SB, Kensinger C, Forbes R, Karp S, Williams P, Roy S, Fissell WH

Original article submission: Platelet stress accumulation analysis to predict thrombogenicity of an artificial kidney.

Journal of biomechanics

Buck AKW, Goebel SG, Goodin MS, Wright NJ, Groszek JJ, Moyer J, Singh S, Bluestein D, Fissell WH, Roy S

Novel Wearable Seismocardiography and Machine Learning Algorithms Can Assess Clinical Status of Heart Failure Patients.

Circulation. Heart failure

Inan OT, Baran Pouyan M, Javaid AQ, Dowling S, Etemadi M, Dorier A, Heller JA, Bicen AO, Roy S, De Marco T, Klein L

Slit pores preferred over cylindrical pores for high selectivity in biomolecular filtration.

Journal of colloid and interface science

Feinberg BJ, Hsiao JC, Park J, Zydney AL, Fissell WH, Roy S

Sterilization effects on ultrathin film polymer coatings for silicon-based implantable medical devices.

Journal of biomedical materials research. Part B, Applied biomaterials

Iqbal Z, Moses W, Kim S, Kim EJ, Fissell WH, Roy S

Silicon Micropore-Based Parallel Plate Membrane Oxygenator.

Artificial organs

Dharia A, Abada E, Feinberg B, Yeager T, Moses W, Park J, Blaha C, Wright N, Padilla B, Roy S

Correction: An intravascular bioartificial pancreas device (iBAP) with silicon nanopore membranes (SNM) for islet encapsulation under convective mass transport.

Lab on a chip

Song S, Blaha C, Moses W, Park J, Wright N, Groszek J, Fissell W, Vartanian S, Posselt AM, Roy S

An intravascular bioartificial pancreas device (iBAP) with silicon nanopore membranes (SNM) for islet encapsulation under convective mass transport.

Lab on a chip

Song S, Blaha C, Moses W, Park J, Wright N, Groszek J, Fissell W, Vartanian S, Posselt AM, Roy S

A distributed solute model: an extended two-pore model with application to the glomerular sieving of Ficoll.

American journal of physiology. Renal physiology

Öberg CM, Groszek JJ, Roy S, Fissell WH, Rippe B

Silicon nanoporous membranes as a rigorous platform for validation of biomolecular transport models.

Journal of membrane science

Feinberg BJ, Hsiao JC, Park J, Zydney AL, Fissell WH, Roy S

Glucose-Stimulated Insulin Response of Silicon Nanopore-Immunoprotected Islets under Convective Transport.

ACS biomaterials science & engineering

Song S, Yeung R, Park J, Posselt AM, Desai TA, Tang Q, Roy S

A modular microfluidic bioreactor with improved throughput for evaluation of polarized renal epithelial cells.

Biomicrofluidics

Brakeman P, Miao S, Cheng J, Lee CZ, Roy S, Fissell WH, Ferrell N

Quantifying and Reducing Motion Artifacts in Wearable Seismocardiogram Measurements During Walking to Assess Left Ventricular Health.

IEEE transactions on bio-medical engineering

Javaid AQ, Ashouri H, Dorier A, Etemadi M, Heller JA, Roy S, Inan OT

Inductive passive sensor for intraparenchymal and intraventricular monitoring of intracranial pressure.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

Behfar MH, Abada E, Sydanheimo L, Goldman K, Fleischman AJ, Gupta N, Ukkonen L, Roy S

Diffusive Silicon Nanopore Membranes for Hemodialysis Applications.

PloS one

Kim S, Feinberg B, Kant R, Chui B, Goldman K, Park J, Moses W, Blaha C, Iqbal Z, Chow C, Wright N, Fissell WH, Zydney A, Roy S

First Implantation of Silicon Nanopore Membrane Hemofilters.

ASAIO journal (American Society for Artificial Internal Organs : 1992)

Kensinger C, Karp S, Kant R, Chui BW, Goldman K, Yeager T, Gould ER, Buck A, Laneve DC, Groszek JJ, Roy S, Fissell WH

Silicon nanopore membrane (SNM) for islet encapsulation and immunoisolation under convective transport.

Scientific reports

Song S, Faleo G, Yeung R, Kant R, Posselt AM, Desai TA, Tang Q, Roy S

Preliminary Diffusive Clearance of Silicon Nanopore Membranes in a Parallel Plate Configuration for Renal Replacement Therapy.

ASAIO journal (American Society for Artificial Internal Organs : 1992)

Kim S, Heller J, Iqbal Z, Kant R, Kim EJ, Durack J, Saeed M, Do L, Hetts S, Wilson M, Brakeman P, Fissell WH, Roy S

MyPectus: First-in-human pilot study of remote compliance monitoring of teens using dynamic compression bracing to correct pectus carinatum.

Journal of pediatric surgery

Harrison B, Stern L, Chung P, Etemadi M, Kwiat D, Roy S, Harrison MR, Martinez-Ferro M

Corrigendum to: Biocompatibility evaluation of a thermoplastic rubber for wireless telemetric intracranial pressure sensor coating.

Journal of the mechanical behavior of biomedical materials

Yang J, Charif AC, Puskas JE, Phillips H, Shanahan KJ, Garsed J, Fleischman A, Goldman K, Roy S, Luebbers MT, Dombrowski SM, Luciano MG

A Wearable Patch to Enable Long-Term Monitoring of Environmental, Activity and Hemodynamics Variables.

IEEE transactions on biomedical circuits and systems

Etemadi M, Inan OT, Heller JA, Hersek S, Klein L, Roy S

Impedance sensing device enables early detection of pressure ulcers in vivo.

Nature communications

Swisher SL, Lin MC, Liao A, Leeflang EJ, Khan Y, Pavinatto FJ, Mann K, Naujokas A, Young D, Roy S, Harrison MR, Arias AC, Subramanian V, Maharbiz MM

Biocompatibility evaluation of a thermoplastic rubber for wireless telemetric intracranial pressure sensor coating.

Journal of the mechanical behavior of biomedical materials

Yang J, Charif AC, Puskas JE, Phillips H, Shanahan KJ, Garsed J, Fleischman A, Goldman K, Roy S, Luebbers MT, Dombrowski SM, Luciano MG

Current strategies and challenges in engineering a bioartificial kidney.

Frontiers in bioscience (Elite edition)

Kim S, Fissell WH, Humes DH, Roy S

Impedance sensing device for monitoring ulcer healing in human patients.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

Liao A, Lin MC, Ritz LC, Swisher SL, Ni D, Mann K, Khan Y, Roy S, Harrison MR, Arias AC, Subramanian V, Young D, Maharbiz MM

Toward continuous, noninvasive assessment of ventricular function and hemodynamics: wearable ballistocardiography.

IEEE journal of biomedical and health informatics

Wiens AD, Etemadi M, Roy S, Klein L, Inan OT

Rapid and low-cost prototyping of medical devices using 3D printed molds for liquid injection molding.

Journal of visualized experiments : JoVE

Chung P, Heller JA, Etemadi M, Ottoson PE, Liu JA, Rand L, Roy S

Imaging assessment of a portable hemodialysis device: detection of possible failure modes and monitoring of functional performance.

Medical instrumentation (Luton, England)

Olorunsola OG, Kim SH, Chang R, Kuo YC, Hetts SW, Heller A, Kant R, Saeed M, Fissell WH, Roy S, Wilson MW

Miniaturizing RFID for magnamosis.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

Jiang H, Chen S, Kish S, Loh L, Zhang J, Zhang X, Kwiat D, Harrison M, Roy S

Tracking clinical status for heart failure patients using ballistocardiography and electrocardiography signal features.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

Etemadi M, Hersek S, Tseng JM, Rabbani N, Heller JA, Roy S, Klein L, Inan OT

Wearable ballistocardiography: preliminary methods for mapping surface vibration measurements to whole body forces.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

Wiens A, Etemadi M, Klein L, Roy S, Inan OT

A low-frequency versatile wireless power transfer technology for biomedical implants.

IEEE transactions on biomedical circuits and systems

Jiang H, Zhang J, Lan D

Towards BirthAlert--A Clinical Device Intended for Early Preterm Birth Detection.

IEEE transactions on bio-medical engineering

Etemadi M, Chung P, Heller JA, Liu JA, Rand L, Roy S

The bioartificial kidney: current status and future promise.

Pediatric nephrology (Berlin, Germany)

Humes HD, Buffington D, Westover AJ, Roy S, Fissell WH

Fabric-based pressure sensor array for decubitus ulcer monitoring.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

Chung P, Rowe A, Etemadi M, Lee H, Roy S

Novel device to trend impedance and fluorescence of the cervix for preterm birth detection.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

Etemadi M, Chung P, Heller JA, Liu J, Grossman-Kahn R, Rand L, Roy S

Implantable ultra-low pulmonary pressure monitoring system for fetal surgery.

IEEE transactions on information technology in biomedicine : a publication of the IEEE Engineering in Medicine and Biology Society

Etemadi M, Heller JA, Schecter SC, Shue EH, Miniati D, Roy S

A feed-forward controlled AC-DC boost converter for biomedical implants.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

Jiang H, Lan D, Lin D, Zhang J, Liou S, Shahnasser H, Shen M, Harrison M, Roy S

Dynamic tracheal occlusion improves lung morphometrics and function in the fetal lamb model of congenital diaphragmatic hernia.

Journal of pediatric surgery

Jelin EB, Etemadi M, Encinas J, Schecter SC, Chapin C, Wu J, Guevara-Gallardo S, Nijagal A, Gonzales KD, Ferrier WT, Roy S, Miniati D

Hemocompatibility of silicon-based substrates for biomedical implant applications.

Annals of biomedical engineering

Muthusubramaniam L, Lowe R, Fissell WH, Li L, Marchant RE, Desai TA, Roy S

Anti-biofouling Sulfobetaine Polymer Thin Films on Silicon and Silicon Nanopore Membranes.

Journal of biomaterials science. Polymer edition

Li L, Marchant RE, Dubnisheva A, Roy S, Fissell WH

The Responsivity of a Miniaturized Passive Implantable Wireless Pressure Sensor.

Proceedings. IEEE Radio and Wireless Symposium

Jiang H, Lan D, Goldman K, Etemadi M, Shahnasser H, Roy S

Basal lamina secreted by MDCK cells has size- and charge-selective properties.

American journal of physiology. Renal physiology

Ferrell N, Groszek J, Li L, Smith R, Butler RS, Zorman CA, Roy S, Fissell WH

Design and analysis of MEMS based PVDF ultrasonic transducers for vascular imaging.

Sensors (Basel, Switzerland)

Chandrana C, Talman J, Pan T, Roy S, Fleischman A

Molecular conformation and filtration properties of anionic Ficoll.

American journal of physiology. Renal physiology

Groszek J, Li L, Ferrell N, Smith R, Zorman CA, Hofmann CL, Roy S, Fissell WH

Silicon induces minimal thromboinflammatory response during 28-day intravascular implant testing.

ASAIO journal (American Society for Artificial Internal Organs : 1992)

Melvin ME, Fissell WH, Roy S, Brown DL

Demonstration of second-harmonic IVUS feasibility with focused broadband miniature transducers.

IEEE transactions on ultrasonics, ferroelectrics, and frequency control

Chandrana C, Kharin N, Vince G, Roy S, Fleischman A

Characterizing the surface charge of synthetic nanomembranes by the streaming potential method.

Journal of colloid and interface science

Datta S, Conlisk AT, Kanani DM, Zydney AL, Fissell WH, Roy S

Permeability - Selectivity Analysis for Ultrafiltration: Effect of Pore Geometry.

Journal of membrane science

Kanani DM, Fissell WH, Roy S, Dubnisheva A, Fleischman A, Zydney AL

A high-power versatile wireless power transfer for biomedical implants.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

Jiang H, Zhang JM, Liou SS, Fechter R, Hirose S, Harrison M, Roy S

The implantable artificial kidney.

Seminars in dialysis

Fissell WH, Roy S

Modulating human connective tissue progenitor cell behavior on cellulose acetate scaffolds by surface microtextures.

Journal of biomedical materials research. Part A

Kim EJ, Boehm CA, Fleischman AJ, Muschler GF, Kostov YV, Roy S

Solute partitioning and filtration by extracellular matrices.

American journal of physiology. Renal physiology

Fissell WH, Hofmann CL, Ferrell N, Schnell L, Dubnisheva A, Zydney AL, Yurchenco PD, Roy S

Post microtextures accelerate cell proliferation and osteogenesis.

Acta biomaterialia

Kim EJ, Boehm CA, Mata A, Fleischman AJ, Muschler GF, Roy S

A three-dimensional scaffold with precise micro-architecture and surface micro-textures.

Biomaterials

Mata A, Kim EJ, Boehm CA, Fleischman AJ, Muschler GF, Roy S

Biomolecular transport through hemofiltration membranes.

Annals of biomedical engineering

Conlisk AT, Datta S, Fissell WH, Roy S

High-Performance Silicon Nanopore Hemofiltration Membranes.

Journal of membrane science

Fissell WH, Dubnisheva A, Eldridge AN, Fleischman AJ, Zydney AL, Roy S

Development of multistage magnetic deposition microscopy.

Analytical chemistry

Nath P, Strelnik J, Vasanji A, Moore LR, Williams PS, Zborowski M, Roy S, Fleischman AJ

Basic Science Symposium II: MEMS Technology.

SAS journal

Roy S, Fleischman A, Benzel EC, Cameron BD, Ferrara L, Goel VK

A preliminary biomechanical evaluation in a simulated spinal fusion model. Laboratory investigation.

Journal of neurosurgery. Spine

Ferrara LA, Gordon I, Coquillette M, Milks R, Fleischman AJ, Roy S, Goel VK, Benzel EC

Quantification of magnetic susceptibility in several strains of Bacillus spores: implications for separation and detection.

Biotechnology and bioengineering

Melnik K, Sun J, Fleischman A, Roy S, Zborowski M, Chalmers JJ

Ficoll is not a rigid sphere.

American journal of physiology. Renal physiology

Fissell WH, Manley S, Dubnisheva A, Glass J, Magistrelli J, Eldridge AN, Fleischman AJ, Zydney AL, Roy S

Development of continuous implantable renal replacement: past and future.

Translational research : the journal of laboratory and clinical medicine

Fissell WH, Fleischman AJ, Humes HD, Roy S

Connective tissue progenitor cell growth characteristics on textured substrates.

International journal of nanomedicine

Mata A, Boehm C, Fleischman AJ, Muschler GF, Roy S

Differentiated growth of human renal tubule cells on thin-film and nanostructured materials.

ASAIO journal (American Society for Artificial Internal Organs : 1992)

Fissell WH, Manley S, Westover A, Humes HD, Fleischman AJ, Roy S

Electrochemical detection and characterization of proteins.

Biosensors & bioelectronics

Smiechowski MF, Lvovich VF, Roy S, Fleischman A, Fissell WH, Riga AT

Continuous flow magnetic cell fractionation based on antigen expression level.

Journal of biochemical and biophysical methods

Schneider T, Moore LR, Jing Y, Haam S, Williams PS, Fleischman AJ, Roy S, Chalmers JJ, Zborowski M

Orthogonal-coil RF probe for implantable passive sensors.

IEEE transactions on bio-medical engineering

Talman JR, Fleischman AJ, Roy S

Spine biomechanics: fundamentals and future.

Clinical neurosurgery

Benzel EC, Kayanja M, Fleischman A, Roy S

A system for micro/nano fluidic flow diagnostics.

Biomedical microdevices

Nath P, Roy S, Conlisk T, Fleischman AJ

Micromachines in spine surgery.

Spine

Benzel E, Ferrara L, Roy S, Fleischman A

Osteoblast attachment to a textured surface in the absence of exogenous adhesion proteins.

IEEE transactions on nanobioscience

Mata A, Su X, Fleischman AJ, Roy S, Banks BA, Miller SK, Midura RJ

Growth of connective tissue progenitor cells on microtextured polydimethylsiloxane surfaces.

Journal of biomedical materials research

Mata A, Boehm C, Fleischman AJ, Muschler G, Roy S

Evaluation of MEMS materials of construction for implantable medical devices.

Biomaterials

Kotzar G, Freas M, Abel P, Fleischman A, Roy S, Zorman C, Moran JM, Melzak J

Biomaterials and implantable devices: discoveries in the spine surgery arena.

Clinical neurosurgery

Benzel EC, Ferrara LA, Roy S, Fleischman AJ