Michael Lesh, MD

Executive Director, Health Technology Innovation
Catalyst

Michael D. Lesh, MD is a physician, scientist and entrepreneur. He earned undergraduate and graduate degrees in Computer Science and Bioengineering from the Massachusetts Institute of Technology (MIT) before entering medical school at the University of California San Francisco (UCSF).

He is currently Executive Director of Health Technology Innovation in the Office of the Vice Chancellor for Business Development, Innovation and Partnership at UCSF whose mission is to commercialize the University's research and inventions. Dr. Lesh focuses on high value digital health and medical device opportunities, mentors entrepreneurs and start-ups, and has ultimate responsibility for the  Catalyst program, UCSF’s translational accelerator.

After completing Internal Medicine training at UCSF and Cardiology and Cardiac Electrophysiology at the Hospital of the University of Pennsylvania, he joined the faculty at UCSF, where he was Chief of Cardiac Electrophysiology. Dr. Lesh's research spanned a wide range from bench to bedside. He pioneered a number of procedures for catheter ablation of cardiac arrhythmias, and is the author of over 300 scientific papers, book chapters and books. Dr. Lesh holds over 200 patents issued or pending, including the fundamental method for pulmonary vein isolation (PVI) for atrial fibrillation, and left atrial appendage occlusion (LAAO) to prevent stroke.

Since 1997, Dr. Lesh has founded a number of medical device companies based on his inventions. Johnson and Johnson (JNJ) acquired his first venture, Atrionix, developer of a novel ultrasound ablation catheter for PVI in AF.

Dr. Lesh founded and was Chairman and CEO of Mitralife, which developed a catheter-based treatment for mitral valve disease and CHF; and Appriva, which developed PLAATO, a percutaneous trans-catheter device for preventing stroke. Mitralife and Appriva were acquired by ev3, Inc. and subsequently Medtronic. He was the founder and CEO of Evera Medical, which developed novel implants for plastic and reconstructive surgery.

Dr. Lesh was founder, Chairman and CEO of Middle Peak Medical (acquired by Symetis SA), which is developing a percutaneous implant to replace surgery for mitral regurgitation.

He is, or has been, on the Board of Directors of HeartScape Technologies (acquired by Roper), Stentys (IPO as STNT), Abate, Inc. (break-through biologic for atopic dermatitis), Sira Medical (futuristic augmented reality for surgical planing), and Cordance Medical (open BBB for treatment of brain disease). Dr. Lesh serves as a mentor to numerous entrepreneurs and participates as an “angel" investor in early stage companies across the healthcare space.

Publications: 

The variable functional effects of the pacing site in normal and scarred ventricles.

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

del Romeral LM, Stillson C, Lesh M, Botvinick E

Percutaneous left atrial appendage transcatheter occlusion (PLAATO system) to prevent stroke in high-risk patients with non-rheumatic atrial fibrillation: results from the international multi-center feasibility trials.

Journal of the American College of Cardiology

Ostermayer SH, Reisman M, Kramer PH, Matthews RV, Gray WA, Block PC, Omran H, Bartorelli AL, Della Bella P, Di Mario C, Pappone C, Casale PN, Moses JW, Poppas A, Williams DO, Meier B, Skanes A, Teirstein PS, Lesh MD, Nakai T, Bayard Y, Billinger K, Trepels T, Krumsdorf U, Sievert H

An endovascular approach to cardioembolic stroke prevention in atrial fibrillation patients.

Pacing and clinical electrophysiology : PACE

Nakai T, Lesh M, Ostermayer S, Billinger K, Sievert H

Percutaneous left atrial appendage transcatheter occlusion to prevent stroke in high-risk patients with atrial fibrillation: early clinical experience.

Circulation

Sievert H, Lesh MD, Trepels T, Omran H, Bartorelli A, Della Bella P, Nakai T, Reisman M, DiMario C, Block P, Kramer P, Fleschenberg D, Krumsdorf U, Scherer D

Clinical outcome after radiofrequency catheter ablation of focal atrial fibrillation triggers.

Journal of cardiovascular electrophysiology

Gerstenfeld EP, Guerra P, Sparks PB, Hattori K, Lesh MD

Electrocardiographic analysis of ectopic atrial activity obscured by ventricular repolarization: P wave isolation using an automatic 62-lead QRST subtraction algorithm.

Journal of cardiovascular electrophysiology

Sippensgroenewegen A, Mlynash MD, Roithinger FX, Goseki Y, Lesh MD

Atypical right atrial flutter patterns.

Circulation

Yang Y, Cheng J, Bochoeyer A, Hamdan MH, Kowal RC, Page R, Lee RJ, Steiner PR, Saxon LA, Lesh MD, Modin GW, Scheinman MM

Is there a role for biatrial pacing in the prevention of atrial arrhythmias?

Journal of cardiovascular electrophysiology

Gerstenfeld EP, Lesh MD

Body surface mapping of counterclockwise and clockwise typical atrial flutter: a comparative analysis with endocardial activation sequence mapping.

Journal of the American College of Cardiology

SippensGroenewegen A, Lesh MD, Roithinger FX, Ellis WS, Steiner PR, Saxon LA, Lee RJ, Scheinman MM

Novel catheter technology for ablative cure of atrial fibrillation.

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing

Lesh MD, Guerra P, Roithinger FX, Goseki Y, Diederich C, Nau WH, Maguire M, Taylor K

Electrophysiologic effects of selective right versus left atrial linear lesions in a canine model of chronic atrial fibrillation.

Journal of cardiovascular electrophysiology

Roithinger FX, Steiner PR, Goseki Y, Sparks PB, Lesh MD

The spatial dispersion of atrial refractoriness and atrial fibrillation vulnerability.

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing

Roithinger FX, Karch MR, Steiner PR, SippensGroenewegen A, Lesh MD

Use of electroanatomic mapping to delineate transseptal atrial conduction in humans.

Circulation

Roithinger FX, Cheng J, SippensGroenewegen A, Lee RJ, Saxon LA, Scheinman MM, Lesh MD

An anatomic approach to prevention of atrial fibrillation: pulmonary vein isolation with through-the-balloon ultrasound ablation (TTB-USA).

The Thoracic and cardiovascular surgeon

Lesh MD, Diederich C, Guerra PG, Goseki Y, Sparks PB

Low-power radiofrequency application and intracardiac echocardiography for creation of continuous left atrial linear lesions.

Journal of cardiovascular electrophysiology

Roithinger FX, Steiner PR, Goseki Y, Liese KS, Scholtz DB, Sippensgroenewegen A, Ursell P, Lesh MD

What is the relationship of atrial flutter and fibrillation?

Pacing and clinical electrophysiology : PACE

Roithinger FX, Lesh MD

Electrophysiologic effects of adenosine in patients with supraventricular tachycardia.

Circulation

Glatter KA, Cheng J, Dorostkar P, Modin G, Talwar S, Al-Nimri M, Lee RJ, Saxon LA, Lesh MD, Scheinman MM

The role of nonpharmacologic therapies for the treatment of atrial fibrillation.

Journal of cardiovascular electrophysiology

Guerra PG, Lesh MD

Use of intracardiac echocardiography during electrophysiologic evaluation and therapy of atrial arrhythmias.

Journal of cardiovascular electrophysiology

Lesh MD, Kalman JM, Karch MR

Narrow complex tachycardia with VA block: diagnostic and therapeutic implications.

Pacing and clinical electrophysiology : PACE

Hamdan MH, Kalman JM, Lesh MD, Lee RJ, Saxon LA, Dorostkar P, Scheinman MM

Organized activation during atrial fibrillation in man: endocardial and electrocardiographic manifestations.

Journal of cardiovascular electrophysiology

Roithinger FX, SippensGroenewegen A, Karch MR, Steiner PR, Ellis WS, Lesh MD

Body surface mapping during pacing at multiple sites in the human atrium: P-wave morphology of ectopic right atrial activation.

Circulation

SippensGroenewegen A, Peeters HA, Jessurun ER, Linnenbank AC, Robles de Medina EO, Lesh MD, van Hemel NM

"Cristal tachycardias": origin of right atrial tachycardias from the crista terminalis identified by intracardiac echocardiography.

Journal of the American College of Cardiology

Kalman JM, Olgin JE, Karch MR, Hamdan M, Lee RJ, Lesh MD

Acute effects of intraoperative multisite ventricular pacing on left ventricular function and activation/contraction sequence in patients with depressed ventricular function.

Journal of cardiovascular electrophysiology

Saxon LA, Kerwin WF, Cahalan MK, Kalman JM, Olgin JE, Foster E, Schiller NB, Shinbane JS, Lesh MD, Merrick SH

Body surface mapping of atrial arrhythmias: atlas of paced P wave integral maps to localize the focal origin of right atrial tachycardia.

Journal of electrocardiology

SippensGroenewegen A, Roithinger FX, Peeters HA, Linnenbank AC, van Hemel NM, Steiner PR, Lesh MD

Potential role of 'hybrid therapy' for atrial fibrillation.

Seminars in interventional cardiology : SIIC

Lesh MD, Kalman JM, Roithinger FX, Karch MR

Electrophysiological effects of long, linear atrial lesions placed under intracardiac ultrasound guidance.

Circulation

Olgin JE, Kalman JM, Chin M, Stillson C, Maguire M, Ursel P, Lesh MD

Electrophysiology of "incisional" reentrant atrial tachycardia complicating surgery for congenital heart disease.

Pacing and clinical electrophysiology : PACE

Lesh MD, Kalman JM, Saxon LA, Dorostkar PC

Mortality benefit of implantable cardioverter-defibrillator therapy in patients with persistent malignant ventricular arrhythmias despite amiodarone treatment.

The American journal of cardiology

Barron HV, Khan HH, Viskin S, Heller K, Kalman JM, Scheinman MM, Lesh MD

Risk of thromboembolism in chronic atrial flutter.

The American journal of cardiology

Wood KA, Eisenberg SJ, Kalman JM, Drew BJ, Saxon LA, Lee RJ, Lesh MD, Scheinman MM

Slow AV nodal pathway ablation utilizing a unique temperature controlled radiofrequency energy system.

Pacing and clinical electrophysiology : PACE

Epstein LM, Jung S, Lee RJ, Lesh MD, Eisenberg SJ, Scheinman MM, Fitzpatrick AP

Mechanism of initiation of atrial flutter in humans: site of unidirectional block and direction of rotation.

Journal of the American College of Cardiology

Olgin JE, Kalman JM, Saxon LA, Lee RJ, Lesh MD

Postextrasystolic U wave augmentation, a new marker of increased arrhythmic risk in patients without the long QT syndrome.

Journal of the American College of Cardiology

Viskin S, Heller K, Barron HV, Kitzis I, Hamdan M, Olgin JE, Wong MJ, Grant SE, Lesh MD

Effect of patient characteristics on the yield of prolonged baseline head-up tilt testing and the additional yield of drug provocation.

Heart (British Cardiac Society)

Fitzpatrick AP, Lee RJ, Epstein LM, Lesh MD, Eisenberg S, Sheinman MM

Long-term results of electrophysiologically guided sotalol therapy for life-threatening ventricular arrhythmias.

American heart journal

Lee RJ, Wong M, Siu A, Namekawa-Wong M, Epstein LM, Fitzpatrick AP, Grogin HR, Scheinman MM, Lesh MD

Mode of onset of torsade de pointes in congenital long QT syndrome.

Journal of the American College of Cardiology

Viskin S, Alla SR, Barron HV, Heller K, Saxon L, Kitzis I, Hare GF, Wong MJ, Lesh MD, Scheinman MM

Pathological findings following slow pathway ablation for AV nodal reentrant tachycardia.

Journal of cardiovascular electrophysiology

Olgin JE, Ursell P, Kao AK, Lesh MD

Results of radiofrequency catheter ablation for atrial flutter.

The American journal of cardiology

Saxon LA, Kalman JM, Olgin JE, Scheinman MM, Lee RJ, Lesh MD

Autonomic nervous system and sudden cardiac death.

Journal of the American College of Cardiology

Barron HV, Lesh MD

Radiofrequency catheter modification of sinus pacemaker function guided by intracardiac echocardiography.

Circulation

Kalman JM, Lee RJ, Fisher WG, Chin MC, Ursell P, Stillson CA, Lesh MD, Scheinman MM

Radiofrequency catheter modification of the sinus node for "inappropriate" sinus tachycardia.

Circulation

Lee RJ, Kalman JM, Fitzpatrick AP, Epstein LM, Fisher WG, Olgin JE, Lesh MD, Scheinman MM

Use of P wave configuration during atrial tachycardia to predict site of origin.

Journal of the American College of Cardiology

Tang CW, Scheinman MM, Van Hare GF, Epstein LM, Fitzpatrick AP, Lee RJ, Lesh MD

Sudden cardiac death and polymorphous ventricular tachycardia in patients with normal QT intervals and normal systolic cardiac function.

The American journal of cardiology

Eisenberg SJ, Scheinman MM, Dullet NK, Finkbeiner WE, Griffin JC, Eldar M, Franz MR, Gonzalez R, Kadish AH, Lesh MD

A direct midseptal approach to slow atrioventricular nodal pathway ablation.

Pacing and clinical electrophysiology : PACE

Epstein LM, Lesh MD, Griffin JC, Lee RJ, Scheinman MM

Radiofrequency catheter ablation of atriofascicular and nodoventricular Mahaim tracts.

Circulation

Grogin HR, Lee RJ, Kwasman M, Epstein LM, Schamp DJ, Lesh MD, Scheinman MM

Effects of simulated potassium blockade on the dynamics of triggered cardiac activity.

Journal of theoretical biology

Gibb WJ, Wagner MB, Lesh MD

Electrophysiological laboratory, electrophysiologist-implanted, nonthoracotomy-implantable cardioverter/defibrillators.

Circulation

Fitzpatrick AP, Lesh MD, Epstein LM, Lee RJ, Siu A, Merrick S, Griffin JC, Scheinman MM

Radiofrequency catheter ablation as a cure for idiopathic tachycardia of both left and right ventricular origin.

Journal of the American College of Cardiology

Coggins DL, Lee RJ, Sweeney J, Chein WW, Van Hare G, Epstein L, Gonzalez R, Griffin JC, Lesh MD, Scheinman MM

Radiofrequency catheter ablation in the treatment of supraventricular tachycardia in the elderly.

Journal of the American College of Cardiology

Epstein LM, Chiesa N, Wong MN, Lee RJ, Griffin JC, Scheinman MM, Lesh MD

Status of ablation in patients with atrial tachycardia and flutter.

Pacing and clinical electrophysiology : PACE

Lesh MD, Van Hare GF

Radiofrequency catheter ablation guided by intracardiac echocardiography.

Circulation

Chu E, Fitzpatrick AP, Chin MC, Sudhir K, Yock PG, Lesh MD

Radiofrequency catheter ablation of atrial arrhythmias. Results and mechanisms.

Circulation

Lesh MD, Van Hare GF, Epstein LM, Fitzpatrick AP, Scheinman MM, Lee RJ, Kwasman MA, Grogin HR, Griffin JC

New algorithm for the localization of accessory atrioventricular connections using a baseline electrocardiogram.

Journal of the American College of Cardiology

Fitzpatrick AP, Gonzales RP, Lesh MD, Modin GW, Lee RJ, Scheinman MM

Ventricular septal summit stimulation in atrioventricular nodal reentrant tachycardia.

The American journal of cardiology

Chien WW, Wang YS, Epstein LM, Cohen TJ, Lesh MD, Griffin JC, Scheinman MM

Curing reentrant atrial arrhythmias. Targeting protected zones of slow conduction by catheter ablation.

Journal of electrocardiology

Lesh MD, Van Hare GF, Fitzpatrick AP, Griffin JC, Chu E

Coronary air embolism complicating transseptal radiofrequency ablation of left free-wall accessory pathways.

Pacing and clinical electrophysiology : PACE

Lesh MD, Coggins DL, Ports TA

Curative percutaneous catheter ablation using radiofrequency energy for accessory pathways in all locations: results in 100 consecutive patients.

Journal of the American College of Cardiology

Lesh MD, Van Hare GF, Schamp DJ, Chien W, Lee MA, Griffin JC, Langberg JJ, Cohen TJ, Lurie KG, Scheinman MM

Patients with supraventricular tachycardia presenting with aborted sudden death: incidence, mechanism and long-term follow-up.

Journal of the American College of Cardiology

Wang YS, Scheinman MM, Chien WW, Cohen TJ, Lesh MD, Griffin JC

Radiofrequency catheter ablation for treatment of bundle branch reentrant ventricular tachycardia: results and long-term follow-up.

Journal of the American College of Cardiology

Cohen TJ, Chien WW, Lurie KG, Young C, Goldberg HR, Wang YS, Langberg JJ, Lesh MD, Lee MA, Griffin JC

Radiofrequency catheter ablation for Wolff-Parkinson-White syndrome associated with a coronary sinus diverticulum.

Pacing and clinical electrophysiology : PACE

Lesh MD, Van Hare G, Kao AK, Scheinman MM

Pacemaker generator pseudomalfunction: an artifact of Holter monitoring.

Pacing and clinical electrophysiology : PACE

Lesh MD, Langberg JJ, Griffin JC, Scheinman MM, Witherell CL